Remarkable developments in genome editing are set to revolutionize medicine agriculture as large animal genomes can, for the first time, be modified with sophistication and efficiency so far only achievable in the mouse. This technology would allow for improvement in livestock production traits, agricultural animal health and welfare, and generation of more refined large animal models for biomedical applications. The summit will bring together reproductive biologists, geneticists, molecular biologists, animal model developers, preclinical and clinical researchers, and representatives of federal research and regulatory agencies.
Following the Large Animal Genetic Engineering Summit at the Bethesda Marriott, the Biotechnology Innovation Organization (BIO) hosts its Animal Biotech Summit: Advancing One Health Through Biotechnology focused on challenges at the nexus of human, animal and environmental health. Learn more here
1. Provide updates on genetic engineering technologies, including genome editing, and their biomedical and agricultural applications in academia and industry.
2. Engage federal agencies, industry representatives and academic researchers in a policy development forum. The focus of this panel discussion will be to: broadly define large animal research areas/topics that include transgenesis; and develop joint strategies to improve funding focused on developing the best animal models for a given trait/disease (dual purpose with dual benefit and beyond).
3. Generate discussion on regulations pertaining to genetically engineered livestock and review the Medical Device Development Tools (MDDT) program.
Sunday, September 18, 2016
|4:00 pm – 6:30 pm||Registration|
|6:00 pm – 8:00 pm||Welcome Reception|
Monday, September 19, 2016
|7:00 am – 6:00 pm||Registration|
|8:00 am – 8:15 am||
Welcome- Kenneth L. White, PhD, Utah State University, USA
|8:15 am – 9:00 am||Michael Roberts, PhD, University of Missouri, USA
Keynote Lecture: The Current Status of Transgenic Farm Animal Research
|Session 1||Gene Editing in Livestock: Technology and Application
Session chair- Bruce Whitelaw, PhD, Roslin Institute, United Kingdom
|9:00 am – 9:30 am||Dan Carlson, PhD, Recombinetics Inc., USA
Efficient Genome Editing in Livestock
|9:30 am – 10:00 am||Göetz Laible, PhD, AgResearch, New Zealand
Technological Advances Create New Opportunities
for the Targeted Improvement of Livestock.
|10:00 am – 10:30 am||
Bhanu Telugu, PhD, University of Maryland, USA
|10:30 am – 10:45 am||Refreshment break/ poster exhibit|
|Session 2||Modification of Disease Resistance and Susceptibility in Large Animals
Session Chair – Chris Davies, DVM, PhD, Utah State University, USA
|10:45 – 11:15 am||Kevin D. Wells, PhD, University of Missouri, USA
Improved resistance to livestock disease through genetic enhancement.
|11:15 – 11:45 am||
Jorge Piedrahita, PhD, North Carolina State University, USA
|11:45 am–12:15pm||Eddie Sullivan, PhD, SAb Biotherapeutics, USA
The Use of Genetically Engineered Large Animals to RapidlyRespond to
Emerging Infectious Disease Through the Production of Therapeutic Antibodies
|12:15 -1:15 pm||Lunch break|
|Session 3||Transgenic Large Animal Models
Session Chair – Kevin D. Wells, PhD, University of Missouri, USA
|1:15 -1:45 pm||
Irina Polejaeva, PhD, Utah State University, USA
Ravi Ranjan, MD, PhD, University of Utah, USA
|1:45 – 2:15 pm||Randy Prather, PhD, University of Missouri, USA
Development of Animal Models and National Swine Research and Resource Center
|2:15 – 2:45 pm||Two selected abstract presentations (15 min each)|
|2:45 – 3:45 pm||Poster Session / refreshment break;
Posters will remain up for the whole meeting to allow ample time for poster viewing.
|Session 4||Regulation and Certification of Genetically Engineered Large Animal Models
Moderator: Mark Walton, PhD, Yorktown Technologies, LP, USA
|3:45 – 4:15 pm||FDA Center for Veterinary Medicine
Current status of regulation for GE livestock generated for
biomedical and agricultural applications
|4:15 – 4:45 pm||Donna Lochner, Senior Scientific Advisor, CDRH, FDA
Introduction to the Medical Device Development Tools (MDDT) program
|4:45 – 5:15 pm||Panel Discussion|
Tuesday, September 20, 2016
|7:00 am – 10:00am||Registration|
|Session 5||Current and Future Large Animal Models in Biomedical Research
Session Chair- Zhongde Wang, PhD, Utah State University, USA
David L. Ayares, PhD, Revivicor Inc, USA
Genetically Engineered Pigs for Xenotransplantation
|8:30 – 9:00 am||Michael Cutler, DO, PhD, Intermountain Heart Institute, USA
Translational Cardiovascular Research Utilizing Large Animal Genetic Engineering
|9:00 – 9:30 am||Chris Rogers, PhD, Exemplar Genetics, USA
|9:30 – 10:00 am||Two selected abstract presentations (15 min each)|
|10:00 – 10:30 am||Refreshment break/ poster exhibit|
|Session 6||Funding Mechanisms to Support Genetically Engineered Livestock Research
Moderator: Kenneth L. White, PhD, Utah State University, USA
|10:30 – 12:00 pm||
Miguel Contreras, PhD, Program Officer, Division of Comparative Medicine, in the Office of Research Infrastructure Programs, located within the Division of Program Coordination, Planning, and Strategic Initiatives, National Institutes of Health, Office of the Director
|12:00 -1:00 pm||Lunch break|
Current and Future Large Animal Models in Biomedical Research
Session chair- Irina Polejaeva, PhD, Utah State University, USA
|1:00 – 1:30 pm||Eckhard Wolf, Gene Center of the LMU, Germany
Genetically Tailored Pig Models for Translational Diabetes Research.
The presentation will also include information on a recently established network on large animal models in the EU
|1:30 – 2:00 pm||Ann Harris, PhD, Northwestern University, USA
Why Might New Large Animal Models of Cystic Fibrosis be useful for Generating New Therapies?
|2:00 – 2:30 pm||Noelle Cockett, PhD, Utah State University, USA
Future Perspectives and Closing Remarks.
Directions on how to get to the Bethesda Marriott from area airports can be found below. This hotel does not provide shuttle service from any of the area airports. If you use the Metro to reach the hotel, the Marriott provides complementary shuttle service from the Medical Center Station to the hotel. When you reach the Medical Center Metro Station call the Bethesda Marriott Hotel at 301-897-9400 they will send the shuttle to pick you up from the station. For more detailed transport information click here.
visit the Utah Agricultural Experiment station website here
Find more information about USTAR here
visit the National Institute of Food and Agriculture here
Visit the National Swine Resource and Research Center here
Visit Simplot Animal Sciences here
Visit the Yorktown Technologies, L.P. website here
Visit SAB Biotherapeutics Inc., here