RESEARCH • APPLICATIONS • POLICY

Remarkable developments in genome editing are set to revolutionize medicine agriculture as large animal genomes can, for the first time, be modified with sophistication and efficiency so far only achievable in the mouse. This technology would allow for improvement in livestock production traits, agricultural animal health and welfare, and generation of more refined large animal models for biomedical applications. The summit will bring together reproductive biologists, geneticists, molecular biologists, animal model developers, preclinical and clinical researchers, and representatives of federal research and regulatory agencies.

September 18-20, 2016

20Days
12Hours
6Mins
9Secs

Posters

Posters for the summit should be 36 inches wide by 48 inches tall or 91.5 centimeters wide by 122 centimeters tall. Posters may be square, however, they may not exceed 36 inches/ 91.5 centimeters wide.

 

 

 

One location. Two great meetings.

Following the Large Animal Genetic Engineering Summit at the Bethesda Marriott, the Biotechnology Innovation Organization (BIO) hosts its Animal Biotech Summit: Advancing One Health Through Biotechnology focused on challenges at the nexus of human, animal and environmental health. Learn more here

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Objectives

The inaugural Large Animal Genetic Engineering Summit will:

 

1. Provide updates on genetic engineering technologies, including genome editing, and their biomedical and agricultural applications in academia and industry.

2. Engage federal agencies, industry representatives and academic researchers in a policy development forum. The focus of this panel discussion will be to: broadly define large animal research areas/topics that include transgenesis; and develop joint strategies to improve funding focused on developing the best animal models for a given trait/disease (dual purpose with dual benefit and beyond).

3. Generate discussion on regulations pertaining to genetically engineered livestock and review the Medical Device Development Tools (MDDT) program.

September 19th Presenters

Irina Polejaeva, PHD

Associate Professor, Utah State University

Bruce Whitelaw, PHD

Head of the Division of Developmental Biology, The Roslin Institute

Donna Lochner

Associate Director, Office of Science and Engineering Laboratories, FDA

Mark Walton, PHD

President, Ornamental Bio, Yorktown Technologies, LP

Chris Davies, DVM, PHD

Research Associate Professor, Utah State University

Kenneth L. White, PHD

Dean, College of Agriculture and Applied Sciences, Utah State University

Eddie Sullivan, PHD

President and CEO, SAB Biotherapeutics

Randy Prather, PHD

Director, National Swine Resource and Research Center, University of Missouri

Jorge Piedrahita, PHD

Director, Comparative Medicine Institute, North Carolina State University

Kevin D. Wells, PHD

Assistant Professor, University of Missouri

Bhanu Telugu, PHD

Assistant Professor, University of Maryland/ Visiting Scientist, USDA and ARS

Göetz Laible, PHD

Senior Scientist, AgReseach

Dan Carlson, PHD

Director of Lab Operations at Recombinetics, Inc

Michael Roberts, PHD

Curators' Professor, University of Missouri

September 20th Presenters

Miguel Contreras, PhD

Program Officer at the Division of Comparative Medicine, Office of Research Infrastructure Programs, National Institutes of Health

Adele Turzillo, PhD

Division Director, USDA National Insititute of Food and Agriculuture

Ravi Ravindranath, DVM, PHD

Program Director, National Institutes of Health

David L. Ayares, PHD

Executive Vice President and Chief Scientific Officer, Revivicor Inc.

Noelle Cockett, PHD

Executive Vice President and Provost, Utah State University

Ann Harris, PHD

Professor, Pediatrics and Human Molecular Genetics, Feinberg School of Medicine, Northwestern University

Chris Rogers, PHD

Chief Scientific Officer, Exemplar Genetics

Michael Cutler, DO, PHD

Elecctrophysiology Specialist, Intermountain Heart Institute

Eckhard Wolf, PHD

Director, Center for Innovative Medical Models, University of Munich Gene Center

Program

Sunday, September 18, 2016

4:00 pm – 6:30 pm Registration
6:00 pm – 8:00 pm Welcome Reception

Monday, September 19, 2016

7:00 am – 6:00 pm Registration
8:00 am – 8:15 am

Welcome- Kenneth L. White, PhD, Utah State University, USA

8:15 am – 9:00 am Michael Roberts, PhD, University of Missouri, USA
Keynote Lecture: The Current Status of Transgenic Farm Animal Research
Session 1 Gene Editing in Livestock: Technology and Application
Session chair- Bruce Whitelaw, PhD, Roslin Institute, United Kingdom
9:00 am – 9:30 am Dan Carlson, PhD, Recombinetics Inc., USA
Efficient Genome Editing in Livestock
9:30 am – 10:00 am Göetz Laible, PhD, AgResearch, New Zealand
Technological Advances Create New Opportunities
for the Targeted Improvement of Livestock.
10:00 am – 10:30 am

Bhanu Telugu, PhD, University of Maryland, USA
Engineering Genomes of Domestic Pigs for Agricultural Applications

10:30 am – 10:45 am Refreshment break/ poster exhibit
Session 2 Modification of Disease Resistance and Susceptibility in Large Animals
Session Chair – Chris Davies, DVM, PhD, Utah State University, USA
10:45 – 11:15 am Kevin D. Wells, PhD, University of Missouri, USA
Improved resistance to livestock disease through genetic enhancement.
11:15 – 11:45 am

Jorge Piedrahita, PhD, North Carolina State University, USA
Development and characterization of severe combine immune deficient swine.

11:45 am–12:15pm  Eddie Sullivan, PhD, SAb Biotherapeutics,  USA
The Use of Genetically Engineered Large Animals to RapidlyRespond to
Emerging Infectious Disease Through the Production of Therapeutic Antibodies
12:15 -1:15 pm Lunch break
Session 3 Transgenic Large Animal Models
Session Chair – Kevin D. Wells, PhD, University of Missouri, USA
1:15 -1:45 pm

Irina Polejaeva, PhD, Utah State University, USA

Ravi Ranjan, MD, PhD, University of Utah, USA
TGF-beta1 Transgenic Goat Model of Atrial Fibrillation

1:45 – 2:15 pm Randy Prather, PhD, University of Missouri, USA
Development of Animal Models and National Swine Research and Resource Center
2:15 – 2:45 pm Two selected abstract presentations (15 min each)
2:45 – 3:45 pm Poster Session / refreshment break;
Posters will remain up for the whole meeting to allow ample time for poster viewing.
Session 4 Regulation and Certification of Genetically Engineered Large Animal Models
Moderator: Mark Walton, PhD, Yorktown Technologies, LP, USA
3:45 – 4:15 pm FDA Center for Veterinary Medicine
Current status of regulation for GE livestock generated for
biomedical and agricultural applications
4:15 – 4:45 pm Donna Lochner, Senior Scientific Advisor, CDRH, FDA
Introduction to the Medical Device Development Tools (MDDT) program
4:45 – 5:15 pm Panel Discussion

Tuesday, September 20, 2016

7:00 am – 10:00am Registration
Session 5 Current and Future Large Animal Models in Biomedical Research
Session Chair- Zhongde Wang, PhD, Utah State University, USA
8:00-8:30 am

David L. Ayares, PhD, Revivicor Inc, USA

Genetically Engineered Pigs for Xenotransplantation

8:30 – 9:00 am Michael Cutler, DO, PhD, Intermountain Heart Institute, USA
Translational Cardiovascular Research Utilizing Large Animal Genetic Engineering
9:00 – 9:30 am Chris Rogers, PhD, Exemplar Genetics, USA
Cancer Models
9:30 – 10:00 am Two selected abstract presentations (15 min each)
10:00 – 10:30 am Refreshment break/ poster exhibit
Session 6 Funding Mechanisms to Support Genetically Engineered Livestock Research
Moderator: Kenneth L. White, PhD, Utah State University, USA
10:30 – 12:00 pm

Panelists include:
Adele Turzillo, Division Director, USDA National Insititute of Food and Agriculuture
Ravi Ravindranath, DVM, PhD, Director for Preimplantation Genetics and Development Program, National Institutes of Health

Miguel Contreras, PhD, Program Officer, Division of Comparative Medicine, in the Office of Research Infrastructure Programs, located within the Division of Program Coordination, Planning, and Strategic Initiatives, National Institutes of Health, Office of the Director

12:00 -1:00 pm Lunch break
SESSION 7:

Current and Future Large Animal Models in Biomedical Research

Session chair- Irina Polejaeva, PhD, Utah State University, USA

1:00 – 1:30 pm Eckhard Wolf, Gene Center of the LMU, Germany
Genetically Tailored Pig Models for Translational Diabetes Research.
The presentation will also include information on a 
recently established network on large animal models in the EU
1:30 – 2:00 pm Ann Harris, PhD, Northwestern University, USA
Why Might New Large Animal Models of Cystic Fibrosis be useful for Generating New Therapies?
2:00 – 2:30 pm Noelle Cockett, PhD, Utah State University, USA 

Future Perspectives and Closing Remarks.

Bethesda Marriott

5151 Pooks Hill Road, Bethesda, Maryland

Book a Hotel Room

 

 

 Directions on how to get to the Bethesda Marriott from area airports can be found below. This hotel does not provide shuttle service from any of the area airports. If you use the Metro to reach the hotel, the Marriott provides complementary shuttle service from the Medical Center Station to the hotel. When you reach the Medical Center Metro Station call the Bethesda Marriott Hotel at 301-897-9400 they will send the shuttle to pick you up from the station. For more detailed transport information click here.

Ronald Reagan Washington National Airport – DCA

Airport Phone: +1 703 417 8000

Hotel direction: 21 miles NE

  • Alternate transportation: Capitol City Transportation; fee: 50 USD (one way); reservation required
  • Bus service, fee: 35 USD  (one way)
  • Metro service, fee:  3.25 USD  (one way). Take the red line to the Medical Center Metro Station
  • Estimated taxi fare: 45 USD  (one way)

Washington Dulles International Airport – IAD

Airport Phone: +1 703 572 2700

Hotel direction: 25 miles NE

  • Alternate transportation: Capitol City Transportation; fee: 60 USD (one way); reservation required
  • Bus service, fee: 45 USD  (one way)
  • Estimated taxi fare: 50 USD  (one way)

Baltimore/Washington International Thurgood Marshall Airport – BWI

Airport Phone: +1 410 859 7111

Hotel direction: 35 miles SW

  • Alternate transportation: Please contact the hotel; fee: 100 USD (one way); reservation required
  • Bus service, fee: 45 USD  (one way)
  • Estimated taxi fare: 60 USD  (one way)

LAGE Registration

Registration

Registration Includes

  • Welcome reception on September 18
  • All sessions
  • Continental breakfast on September 19-20
  • Lunch on September 19-20

Sponsors

Platinum

visit the Utah Agricultural Experiment station website here
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Find more information about USTAR here

Gold

visit the National Institute of Food and Agriculture here

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Silver

Visit the National Swine Resource and Research Center here

NSRRC

 

Bronze

Visit TransOva

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Visit Simplot Animal Sciences here

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Visit the Yorktown Technologies, L.P. website here

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Visit SAB Biotherapeutics Inc., here

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