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2016 Recap

Sunday, September 18, 2016

4:00 pm – 6:30 pm Registration
6:00 pm – 8:00 pm Welcome Reception

Monday, September 19, 2016

7:00 am – 6:00 pm Registration
8:00 am – 8:15 am

Welcome- Kenneth L. White, PhD, Utah State University, USA

8:15 am – 9:00 am Michael Roberts, PhD, University of Missouri, USA
Keynote Lecture: The Current Status of Transgenic Farm Animal Research
Session 1 Gene Editing in Livestock: Technology and Application
Session chair- Bruce Whitelaw, PhD, Roslin Institute, United Kingdom
9:00 am – 9:30 am Dan Carlson, PhD, Recombinetics Inc., USA
Efficient Genome Editing in Livestock
9:30 am – 10:00 am Göetz Laible, PhD, AgResearch, New Zealand
Technological Advances Create New Opportunities
for the Targeted Improvement of Livestock.
10:00 am – 10:30 am

Bhanu Telugu, PhD, University of Maryland, USA
Engineering Genomes of Domestic Pigs for Agricultural Applications

10:30 am – 10:45 am Refreshment break/ poster exhibit
Session 2 Modification of Disease Resistance and Susceptibility in Large Animals
Session Chair – Chris Davies, DVM, PhD, Utah State University, USA
10:45 – 11:15 am Kevin D. Wells, PhD, University of Missouri, USA
Improved resistance to livestock disease through genetic enhancement.
11:15 – 11:45 am

Jorge Piedrahita, PhD, North Carolina State University, USA
Development and characterization of severe combine immune deficient swine.

11:45 am–12:15pm Eddie Sullivan, PhD, SAb Biotherapeutics, USA
The Use of Genetically Engineered Large Animals to RapidlyRespond to
Emerging Infectious Disease Through the Production of Therapeutic Antibodies
12:15 -1:15 pm Lunch break
Session 3 Transgenic Large Animal Models
Session Chair – Carol Keefer, PhD, University of Maryland, USA
1:15 -1:45 pm Irina Polejaeva, PhD, Utah State University, USA
Ravi Ranjan, MD, PhD, University of Utah, USA
TGF-beta1 Transgenic Goat Model of Atrial Fibrillation
1:45 – 2:15 pm Randy Prather, PhD, University of Missouri, USA
Development of Animal Models and National Swine Research and Resource Center
2:15 – 2:45 pm Abstract presentations (15 min each)
Amy Desaulniers, University of Nebraska: Use of Genetically Engineered Swine to Elucidate Testicular Function in the Boar
Seon-Ung Hwang, Chungbuk National University, Korea: Production of Transgenic Pigs with pGFAP-CreERT2; EGFPLoxP Inducible System
2:45 – 3:45 pm Poster Session / refreshment break;
Posters will remain up for the whole meeting to allow ample time for poster viewing.
Session 4 Regulation of Genetically Engineered Large Animal Models and Medical Device Development Tools
Moderator: Mark Walton, PhD, Yorktown Technologies, LP, USA
Presentations followed by panel discussion
3:45- 4:15 pm Malini Wileman, PhD, Center for Veterinary Medicine, FDA, USA
4:15- 4:45 pm Donna Lochner, Center for Devices and Radiological Health, FDA, USA
4:45- 5:15 pm The panel discussion will include the previous presenters and
Jill Ascher, DVM, MPH, Division of Veterinary Services, Center for Biologics Evaluation and Research, FDA, USA
Laura R. Epstein, J.D., Center for Veterinary Medicine, FDA, USA

Tuesday, September 20, 2016

7:00 am – 10:00am Registration
Session 5 Current and Future Large Animal Models in Biomedical Research
Session Chair- Zhongde Wang, PhD, Utah State University, USA
8:00-8:30 am David L. Ayares, PhD, Revivicor Inc, USA
Genetically Engineered Pigs for Xenotransplantation
8:30 – 9:00 am Michael Cutler, DO, PhD, Intermountain Heart Institute, USA
Translational Cardiovascular Research Utilizing Large Animal Genetic Engineering
9:00 – 9:30 am Chris Rogers, PhD, Exemplar Genetics, USA
Cancer Models
9:30 – 10:00 am Abstract presentations (15 min each)
Timothy Sheets, University of Maryland: Investigating the Conserved Role of Neurogenin 3 (NGN3) in Endocrine Pancreatic Development in the Porcine Model Using CRISPR/Cas9 System
Min Yang, Utah State University: Introduction of Callipyge Mutation into the Goat Genome Using Transcription Activator- like Effector Nucleases (TALENs)
10:00 – 10:30 am Refreshment break/ poster exhibit
Session 6 Funding Mechanisms to Support Genetically Engineered Livestock Research
Presentations followed by a panel discussion
Moderator: Kenneth L. White, PhD, Utah State University, USA
10:30- 10:50 am Ravi Ravindranath, D.V.M, PhD
Program Director, Preimplantation Genetics and Development
Fertility and Infertility Branch
The Eunice Kennedy Shrivier National Institute of Child Health and Human Development
National Institutes of Health
10:50- 11:10 am Adele Turzillo, PhD
Director, Division of Animal Systems
USDA National Institute of Food and Agriculture
11:10- 11:30 am Miguel Contreras, PhD
Program Officer, Division of Comparative Medicine
Office of Research Infrastructure Programs | DPCPSI | OD
National Institutes of Health
Panel discussion including presenters and
11:30- 12:00 pm Michael Roberts, PhD
Curators’ Professor of Biochemistry and Animal Sciences
University of Missouri
Member of the National Academy of Sciences
12:00 -1:00 pm Lunch break
Session 7 Current and Future Large Animal Models in Biomedical Research
Session chair- Jon Oatley, PhD, Washington State University, USA
1:00 – 1:30 pm Eckhard Wolf, Gene Center of the LMU, Germany
Genetically Tailored Pig Models for Translational Diabetes Research.
The presentation will also include information on a
recently established network on large animal models in the EU
1:30 – 2:00 pm Ann Harris, PhD, Northwestern University, USA
Why Might New Large Animal Models of Cystic Fibrosis be useful for Generating New Therapies?
2:00 – 2:30 pm Noelle Cockett, PhD, Utah State University, USAFuture Perspectives and Closing Remarks.